Some machines are paused and when trying to unpause they get an error when trying to start the application, has anyone encountered this error? If yes, how to resolve it?

Unfortunately, this is an old problem and apparently has not been resolved yet.

if the user has sufficient rights on the local device, instead of disabling the protection, he will pause it (just pause, and not by time or until a reboot). then you can also resume the operation of components (disable pauses) only from the local client.

You will need to manually launch protection locally on all such devices. There is no other solution yet.