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Server 2008 DC Replication Stops

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Got a weird issue that has started recently where the 2 dc's we have in the domain ( on different sites connected by a VPN ) replication stops with 'Unable to contact the RPC server' error. if I temporarily disable Kaspersky for say 2 or 3 minutes replication starts again, its OK for approx 10 hours then it fails again, then we disable / re enable KES it works again.

Both DC's are windows Server 2008 R2, 

Kaspersky is KES 10

As far as I'm aware there's been no update or change to either server when this issue started. Has anyone seen this issue before? are there any specific policy settings for DC's?

Everything else seems to be working OK.



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