Yes, Kaspersky Antivirus for windows workstation run in Microsoft Windows XP Professional x64 Edition.
http://www.kaspersky.com/anti-virus_windows_workstationQUOTE
System Requirements
Hardware Requirements
* 50 MB available HDD space
* CD-ROM drive (for installing the program from CD)
* Microsoft Internet Explorer 5.5 or higher (for updating threat signatures and application modules over the Internet)
* Microsoft Windows Installer 2.0
Software Requirements
Microsoft Windows Vista
Microsoft Windows Vista x64
Note: Microsoft Windows Vista SP1 supports Kaspersky Anti-Virus for Windows Workstation 6.0.3.837 and higher
* Intel Pentium processor 800 MHz 32-bit (x86)/ 64-bit (x64) or higher (or a compatible CPU)
* 512 MB available RAM
Microsoft Windows 2000 Professional (Service Pack 4 or higher)
Microsoft Windows XP Home Edition
Microsoft Windows XP Professional (Service Pack 1 or higher)
Microsoft Windows XP Professional x64 Edition
* Intel Pentium processor 300 MHz or higher (or a compatible CPU)
* 128 MB available RAM
Microsoft Windows 98(SE)
Microsoft Windows ME
Microsoft Windows NT Workstation 4.0 (Service Pack 6a)
* Intel Pentium processor 300 MHz or higher (or a compatible CPU)
* 64 MB available RAM
Send more info, which version, which build, configuration, domain, etc...
Regards